Of course, ASE is gonzo, and the Tower is pretty scientific and nonspecific, so it wouldn't be out of place to just run the Tower straight. However, I do want it to be a good introduction to the ASE style of gonzo, and it will need to hook into the titular megadungeon.
1. The statue. I'm not sure if ASE has any medusas, but some weird folktale just won't cut it. I'm not even sure medusas even exist in the Land. Instead, it'll be a statue of Torpo the Cannibal fighting the Sasquatch Khan, tying in nicely with Obelisk of Forgotten Memories.
2. The prison. While the quasi-spectral undead were pretty effective here, I wasn't quite sure how much I liked that they charged as soon as you open the door. Yes, I get that it's a lesson for listening, first, but not quite in the theme of voluntarily triggered traps. Instead, we'll get a Sasquetron (also replacing the fifteen-armed skeleton) that turns on if the party takes the key ring off the hook. The dead guy and parasite will remain, although it will use the parasite mechanics from Obelisk of Forgotten Memories.
3. The telescope. The control panel will gain an "aiming" dial, with two black ink marks. The leftmost mark points the telescope (rotating the whole fist) at Mt. Rendon - this is the current setting. The right hand one points it at the Inn of the Alabaster Surprise's courtesan changing room. Other settings do move the telescope but refocusing to get a usable image is a laborious week-long process. However, the beam's deceleration process hasn't yet been figured out, and depending on how it's aimed you will either miss your target and go flying into space, possibly becoming an Orbital God, or otherwise blasting a person-shaped hole in the surface and dying instantly.
4. The books. Some of the books are good as-is, but all the Eldritch Library books about communicating with space aliens are instead equally deranged histories of the Land of 1,000 Towers.
5. Appearance. Obviously, the tower is going to look like a huge stone arm, with the dome being a clenched steel fist. Plus, when the telescope extends, it takes the place of the middle finger.